REMARK (REporting recommendations for tumour MARKer prognostic studies) guides prognostic marker studies in oncology.

Improve reporting of prognostic tumor marker research.

Who should use it

Oncology researchers reporting prognostic biomarker studies.

Recommended for tumor marker prognostic studies.

• Patient population and design
• Marker measurement methods
• Statistical methods
• Results with effect estimates
• Discussion of limitations

• Marker assay methods described
• Predefined analysis plan
• Validation approach if applicable

• Post hoc cutpoint selection
• Missing assay validation
• Overfitting in development datasets